There are 12 Federally listed endangered species of animals in the Black Warrior River basin.

There are two endangered fish: Watercress Darter (Etheostoma nuchale) and Vermilion Darter (Etheostoma chermocki).

One endangered snail: the Plicate rocksnail (Leptoxis ampla).

Nine threatened or endangered species of mussels including: the Triangular kidneyshell (Ptychobranchus greenii), Southern combshell (Epioblasma penita), and Inflated Heelsplitter (Potarnilus inflatus).

There is also a threatened reptile, the Flattened Musk Turtle (Sternotherus depressus) and an amphibian threatened list candidate species, the Black Warrior Waterdog (Necturus alabamensis).